Table 4 HBIS positively correlated to EFC_4 and manually identified with MetaCyc database

Spermidine synthase

2.5.1.16

0.764993

 − 0.340411

Reduction in mortality due to cardiovascular disease

[42, 43]

Porphobilinogen synthase

4.2.1.24

0.590898

-

Heme biosynthesis

[44]

Mycothiol synthase

2.3.1.189

0.771842

 − 0.319983

Antibacterial and antitumoral properties

[45, 46]

Hydrogenobyrinic acid a,c-diamide synthase

6.3.5.9

0.642982

 − 0.284009

Coenzyme B12 (cobalamin) biosynthesis

[47, 48]

Cystathionine gamma-synthase

2.5.1.48

0.712590

 − 0.256458

Energy metabolism, muscle performance, antioxidant

[49,50,51,52,53,54]

Glutamate synthase (NADPH)

1.4.1.13

0.623222

-

Excitatory neurotransmitter, homocysteine balance

[55,56,57,58]

Asparagine synthase

6.3.5.4

0.645870

-

Excitatory neurotransmitter, homocysteine balance

[55,56,57,58]

Glutaminyl-tRNA synthase

6.3.5.7

0.768508

 − 0.284009

Excitatory neurotransmitter, homocysteine balance

[55,56,57,58]