Fig. 2

Response of plasma bioactive lipids to the dietary intervention. Panels show results for A polyunsaturated fatty acids (PUFAs), endocannabinoidome mediators classes, B N-acylethanolamines (NAEs), and C monoacylglycerols (MAGs) and D short-chain fatty acids (SCFAs) and branched-chain fatty acids (BCFAs). The graph represents the mean with the standard error of the log2 ratio between the plasmatic lipid concentrations at MedDiet (V2) vs Baseline (V1) (top panel), CanDiet (V3) vs MedDiet (V2) (middle panel), and MedDiet (V4) vs CanDiet (V3) (bottom panel). The red line drawn at 0 represents no change in the metabolite. Lipid concentrations have been normalized using ranked values fitted into mixed linear-effect model (LME) and differences between visits have been tested by analysis of variance (ANOVA). P-values have been corrected by false discovery rate (FDR). Significance was set at p<0.1 (.), p<0.05 (*), p<0.01 (**), and p<0.001 (***). Names of the molecules are arachidonic acid (AA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), anandamide (AEA), N-docosahexaenoyl-ethanolamine (DHEA), N­eicosapentaenoyl-ethanolamine (EPEA), N-linoleoyl-ethanolamine (LEA), N-oleoyl-ethanolamine (OEA), N-palmitoyl-ethanolamine (PEA), 2-arachidonoyl-glycerol (2-AG), 2-docosahexaenoyl-glycerol (2-DHG), docosaepentaenoic-glycerol (2-DPG), 2-eicosapentaenoyl-glycerol (2-EPG), 2-linoleoyl-glycerol (2-LG), 2-oleoyl-glycerol (2-OG) and 2-palmitoyl-glycerol (2-PG)