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Fig. 8 | Microbiome

Fig. 8

From: Over supplementation with vitamin B12 alters microbe-host interactions in the gut leading to accelerated Citrobacter rodentium colonization and pathogenesis in mice

Fig. 8

DESeq2 differential expression analyses of Lachnospiraceae and Citrobacter-specific functional activity from the EPC experiment. Prior to infection, the functional activity of the Lachnospiraceae family (a) shows that cyanocobalamin treatment increased the expression of numerous genes, including fibronectin type 3 domain-containing protein and serine/threonine transport SstT. b After exposure to C. rodentium, the Lachnospiraceae family members of the inf_CNCbl40 group displayed distinct activities compared to inf_CON group. Citrobacter-specific gene expression (c) was more pronounced in the inf_CNCbl40 group than inf_CON with notable signals of increased virulence gene expression, while control mice had more family 31 glucosidase activity (n = 8; bolded taxa represent a trend (P < 0.10); *P < 0.05, **P < 0.01)

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Microbiome

ISSN: 2049-2618

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