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Fig. 4 | Microbiome

Fig. 4

From: Over supplementation with vitamin B12 alters microbe-host interactions in the gut leading to accelerated Citrobacter rodentium colonization and pathogenesis in mice

Fig. 4

Comparison of the colonic microbial communities in naïve C3H/HeOuJ mice from the SURV and EPC experiments. a Unweighted UniFrac PCoA plot and b weighted UniFrac comparison show a similar pattern in microbial community clustering (Additional file 1 Table S2). c The changes were associated with a consistent reduction in alpha diversity (Observed and PD) regardless of experiment (n = 10–12; P < 0.05). Differential expression determined by DEseq2 analysis also showed that the Firmicutes populations (Clostridia vadinBB60 group) were impacted by cyanocobalamin in both mice harboring d SURV and e EPC gut microbiota (n = 10–12; bolded taxa represent a trend (P < 0.10; *P < 0.05, **P < 0.01, ***P < 0.001)

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