Skip to main content
Fig. 3 | Microbiome

Fig. 3

From: Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization

Fig. 3

Microbial functional analysis in mice transplanted with the feces of NBW and LBW piglets (n = 8). A LEfSe analysis of the predicted microbial function based on PICRUSt2 between LBW and NBW groups. Differential enrichment of 7α-hydroxysteroid dehydrogenase (7α-HSDH) and BA 7-dehydroxylation (baiJ)-positive bacteria in the feces of LBW and NBW piglets (B) or colonic digesta of LBW-FMT and NBW-FMT mice (C) based on PICRUSt2 functional prediction. Gene copy numbers of baiJ, BA hydrolase (bsh), 7α-HSDH, 7β-HSDH, and 12α-HSDH in feces of LBW and NBW piglets (D) or the colonic digesta of LBW-FMT and NBW-FMT mice (E) based on the qPCR analysis. F The synthesis pathway of UDCA by microbial biotransformation from CA and CDCA. G Spearman correlation between the gene copy numbers of individual BA-metabolizing genes and the concentrations of BAs in feces of LBW and NBW piglets. Data are presented as means ± SEM in panels B, C, D, and E. *P < 0.05, **P < 0.01. LBW-FMT, mice transplanted with the feces of LBW piglets; NBW-FMT, mice transplanted with the feces of NBW piglets

Back to article page

Microbiome

ISSN: 2049-2618

Contact us