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Fig. 11 | Microbiome

Fig. 11

From: Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization

Fig. 11

Involvement of FXR in UDCA-mediated anti-inflammatory effects in LPS-treated J774A.1 cells (n = 3). Shown are the expressions of FXR and TGR5 mRNA (A) and FXR protein (B) in response to 1 μg/mL LPS with or without 1 mM UDCA. C The FXR expression after FXR siRNA interference. D FXR knockdown on phosphorylation of p65 NF-κB. Data are presented as means ± SEM. *P < 0.05, versus the control group, #P < 0.05, versus LPS, &P < 0.05, versus the LPS+UDCA group. E the mRNA expressions of IL-1β and TNF-α in response to 1 μg/mL LPS, 1 mM UDCA and/or FXR siRNA. Data are presented as means ± SEM. *P < 0.05, **P < 0.01, *** P < 0.001

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Microbiome

ISSN: 2049-2618

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