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Fig. 6 | Microbiome

Fig. 6

From: Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation

Fig. 6

Correlation between the microbiome composition and phenotypic variables. A The correlation of top focus metabolites and the signature microbiota (Spearman correlation test, FDR < 0.05). B The contents of acetate in the feces (n = 8). C The contents of propionate in the feces (n = 8). D The contents of butyrate in the feces (n = 8). E The levels of LPS in the hippocampus (n = 7). F Relative abundance of colonic Aeromonas (n = 7). G Plots of correlation analysis between the fecal level of butyrate and colonic Aeromonas. X-axis represented the Relative abundance of colonic Aeromonas; Y-axis represented the fecal butyrate levels. CON-FMT: receiving control microbiota FMT mice, SD-FMT: receiving sleep deprivation microbiota FMT mice, SD + Mel-FMT: receiving SD + Mel (20 mg/kg) microbiota FMT mice. The data represent the mean ± SEM, p < 0.05 was set as the threshold for significance by one-way ANOVA followed by post hoc comparisons using Tukey’s test for multiple groups’ comparisons, *p < 0.05, **p < 0.01, ***p < 0.001

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Microbiome

ISSN: 2049-2618

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