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Fig. 3 | Microbiome

Fig. 3

From: Multi-omics profiles of the intestinal microbiome in irritable bowel syndrome and its bowel habit subtypes

Fig. 3

Inter-omic comparison of bacterial taxonomy and function demonstrated upregulation in IBS of transcripts involved in the succinate pathway of carbohydrate fermentation. A Scatterplots depicting median relative abundances of genera in 16S rRNA sequence data and in the metatranscriptome for the 322 subjects with both data types available. B Median ratios of genus abundances in the metatranscriptome (RNA) vs. 16S data (DNA) are plotted for IBS subjects and HC. C Scatterplots of median gene abundances in the predicted metagenome compared to median transcript abundances. D Median transcript/gene abundance ratios are plotted for IBS subjects and HC. Transcripts that were significantly upregulated or downregulated in IBS compared to HC (adjusting for batch, age, sex, race/ethnicity, BMI, dietary category, and HAD-A) are colored. E Pathways that were significantly enriched in differentially regulated transcripts were identified. Significant transcripts within these pathways (represented by dot color) are shown, with dot size proportional to RNA/DNA ratio. Bars indicate standard error of log2 fold change estimates. F Succinate pathway of carbohydrate fermentation. Enzymes transcriptionally upregulated in IBS are colored blue

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