Characteristics | Control (n = 20) | Mild-CKD (n = 15) | Mod-CKD (n = 27) | ESRD (n = 26) | p-value |
---|---|---|---|---|---|
Male, n (%) | 7 (35.0) | 7 (46.7) | 8 (34.5) | 12 (54.5) | 0.143 |
Age (years), mean (SD) | 56.1 (11.0) | 53.0 (15.8) | 60.4 (9.8) | 59.8 (10.6) | 0.365 |
BMI (kg/m2), mean (SD) | 22.8 (2.1) | 25.3 (2.5) | 25.6 (4.4) | 23.8 (3.9) | 0.052 |
Cause of CKD, n (%) | 0.735 | ||||
Diabetes | — | 1 (6.7) | 5 (18.5) | 8 (30.8) | |
Hypertension | — | 1 (6.7) | 3 (11.1) | 3 (11.5) | |
Glomerulonephritis | — | 4 (26.7) | 6 (22.2) | 5 (19.2) | |
Nephrotic syndrome | — | 3 (20.0) | 5 (18.5) | 3 (11.5) | |
Polycystic kidney disease | — | 1 (6.7) | 2 (7.4) | 2 (7.7) | |
Others | — | 5 (33.3) | 6 (22.2) | 5 (19.2) | |
Comorbidities, n (%) | |||||
Type 2 diabetes | — | 1 (6.7) | 8 (29.6) | 12 (46.2) | 0.024 |
Hypertension | — | 3 (20.0) | 19 (70.4) | 20 (76.9) | < 0.001 |
Laboratory index, median (IQR) | |||||
eGFR (ml/min/1.73 m2) | 106.5 (98.2–117.0) | 82.7 (67.8–107.1) | 25.8 (19.0–40.3) | 7.1 (4.9–9.6) | < 0.001 |
Serum creatinine (μmol/L) | 57.5 (49.5–60.8) | 87.5 (78.3–99.0) | 181.0 (151.0–238.0) | 593.0 (471.5–806.0) | < 0.001 |
WBC (× 1012/L) | 6.3 (4.6–7.0) | 5.9 (5.3–7.4) | 6.7 (5.3–7.7) | 5.9 (5.1–6.7) | 0.408 |
Hemoglobin (g/L) | 144.5(136.3–152.8) | 141.5 (126.0–149.5) | 111.0 (98.0–129.0) | 88.5 (77.8–101.0) | < 0.001 |
AST (U/L) | 15.0 (12.5–23.0) | 14.5 (9.4–23.5) | 12.1 (8.7–22.0) | 17.8 (10.7–37.0) | 0.286 |
ALT (U/L) | 18.9 (16.5–22.3) | 16.2 (15.2–22.3) | 16.0 (15.5–20.5) | 16.7 (11.0–23.8) | 0.474 |
Albumin (g/L) | 47.6 (47.6–51.6) | 42.4 (33.8–45.5) | 40.0 (36.2–43.2) | 36.5 (32.6–40.8) | < 0.001 |
Triglycerides (mg/dL) | 1.7 (1.3–2.2) | 1.9 (1.3–2.6) | 2.3 (1.6–3.3) | 1.4 (1.0–2.5) | 0.073 |
Total cholesterol (mg/dL) | 4.6 (4.5–5.5) | 4.8 (4.1–5.7) | 4.3 (3.6–5.1) | 4.2 (3.5–5.1) | 0.209 |