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Table 4 Odds ratios (OR) and 95% confidence intervals (CIs) for summed network module abundance and future early childhood caries case status from logistic regressions stratified by visit (12- or 24-month visit) among 189 children in a nested case-control study selected from the Center for Oral Health Research in Appalachia 2 cohort study

From: Evaluating the ecological hypothesis: early life salivary microbiome assembly predicts dental caries in a longitudinal case-control study

Characteristic

Unadjusted

Adjusted1

Sensitivity2

N3

Case N

OR4

95% CI4

p value

N3

Case N

OR4

95% CI4

p value

N5

Case N

OR4

95% CI4

p value

12-month saliva samples

 Veillonella ASV5 and Streptococcus ASV8 network

159

83

1.04

1.01, 1.06

0.002

159

83

1.04

1.02, 1.07

< 0.001

154

79

1.04

1.02, 1.07

< 0.001

 Haemophilus parainfluenzae and Neisseria ASV9 network

159

83

0.94

0.92, 0.97

< 0.001

159

83

0.94

0.91, 0.97

< 0.001

154

79

0.94

0.91, 0.97

< 0.001

24-month saliva samples

 Veillonella ASV5 and Streptococcus ASV8 network

133

68

1.04

1.01, 1.08

0.008

133

68

1.05

1.01, 1.09

0.009

129

65

1.04

1.01, 1.09

0.019

 Haemophilus parainfluenzae and Neisseria ASV9 network

133

68

0.95

0.92, 0.99

0.016

133

68

0.96

0.92, 1.00

0.043

129

65

0.95

0.91, 1.00

0.033

  1. 1 Model adjusted for: maternal education, count of emerged primary teeth, breastfeeding, antibiotic exposure within 3 months and visit of case diagnosis
  2. 2: Model adjusted for: all variables listed above + weekly frequency child consumes fruit juice (beverage composed of 100% fruit juice) and brushing/wiping of child’s teeth
  3. 3To ensure the salivary bacteriome is prospectively predicting future early childhood caries diagnosis, cases which were diagnosed at 12 months and corresponding controls (N = 6) were excluded from 12-month models. Similarly, cases and diagnosed at 24 months and corresponding controls (N = 37 at 24 months) were excluded from 24-month models. Includes duplicate records for 1 child selected as a control at 36 months and a case at 60 months, and 1 child selected as a control for both 36- and 60-month risk sets. 1 child with missing delivery excluded
  4. 4OR odds ratio, CI confidence interval
  5. 5 Sample size as described in footnote 3, but additionally children with missing dietary or oral hygiene data (n = 5 at 12 months, n = 4 at 24 months) were excluded