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Fig. 1 | Microbiome

Fig. 1

From: Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease

Fig. 1

Gut microbiota of children developing CD was significantly altered at the ASV level. A Box plots showing the comparison between CD progressors (n=9–15) and healthy controls (n=13–16): the alpha diversity measured by observed ASVs (left panel) and the beta diversity measured by Bray–Curtis dissimilarity (right panel). Statistical analysis was performed using ANOVA (alpha diversity) and PERMANOVA (Bray-Curtis distance). B Principal component analysis (PCA) ordination of sample similarity/dissimilarity between CD progressors and healthy controls at age 2.5 and 5 years old. Each circle represents an individual sample, control (green bar) and celiac (red bar). C, D Average relative abundance of bacterial phylum (upper panel) or genera (lower panel) of greater than 1% abundance (proportion) between the gut microbiota of CD progressors and healthy controls at age, 2.5, and 5 years old (taxa average relative abundance>1%). Statistical analysis was performed using two-tailed t tests with the Benjamini and Hochberg method to control the false discovery rate (FDR). E Empirical Bayes quasi-likelihood F tests analysis for the comparisons of gut microbiota ASVs between CD progressors and healthy controls at ages 2.5 and 5 years old. Frequency: number of ASVs. F Heat map showing the relative abundance of the top ASVs significantly different between CD progressors and healthy controls. Each column represents an individual participant, and each row represents an ASV

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