Fig. 4
From: Th17 cells sense microbiome to promote depressive-like behaviors
Microbiomes of depressed patients are sufficient to promote depressive-like behaviors in mice and activate a Th17-dependent pathway. Wild-type (WT), RORγT+/GFP, CCR6−/− germ-free-like mice received 50 mg of stools resuspended in PBS from healthy controls (HC) or depressed patients (DEP) at a ratio 1 stool for 1 recipient, and immobile time in the tail suspension test (A), the number of nose contacts in the sociability test (B), and the numbers of escape failures in the learned helplessness paradigm (C) were reported. Each symbol represents an individual mouse. Data are means ± SEM. n = 5–10 mice/group, one-way ANOVA, F(3, 32) = 2.845, p = 0.0549 (TST); F(3, 35) = 15.24 (sociability); F(3, 35) =2.962 (learned helplessness); Bonferroni post hoc analysis *p<0.05