Fig. 4
From: Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity
Tryptophan availability modulates CNS autoimmunity in a microbiota-dependent fashion. A Schematic of microbiome transplantation and dietary tryptophan modulation model. Ex-germ-free mice received either B6, B6+L. reuteri, or PWD cecal microbiota transplantation, denoted B6→B6-GF (n=38), B6+L. reuteri→B6-GF (n=37), or PWD→B6-GF (n=22), serving as G0 breeding pairs for the vertical transmission model. Offspring were randomized to either a low (0.02%) or high (0.8%) tryptophan diet 1 week prior to EAE induction and serum was collected from naïve and post-EAE mice (B). C–H EAE was evaluated in ex-GF GMT recipients reflected as mean daily clinical score, with overall significance determined by Friedman’s non-parametric two-way ANOVA and one-way ANOVA of area under the curve (AUC)