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Fig. 1 | Microbiome

Fig. 1

From: Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity

Fig. 1

Lactobacillus isolates are highly divergent, displaying global differences in metabolic potential. Taxonomic classification of representative draft genomes for L. reuteri (A), L. murinus (B), and L. johnsonii (C) queried against the NCBI non-redundant prokaryotic genomes database with p-values representing confidence of phylogenetic assignment. D–F Nearest subspecies phylogenetic neighbor of each Lactobacillus draft genome determined by percent shared genomic content graphed as average nucleotide identity (ANI) verses average amino acid identity (AAI). G AAI represented as a phylogenetic tree of Lactobacillus isolates and publicly available reference genomes for strains of the same species. Color ranges denote each species with L. reuteri in blue, L. murinus in red, and L. johnsonii in green with direct isolates and nearest subspecies phylogenetic neighbors labeled in red. Outer color strip specifies originating host for each isolate. H Pie chart of core and accessory inferred proteomic elements between isolates leveraged for I KEGG pathway enrichment analysis of the L. reuteri identified accessory genome. (Top 25 enriched pathways at p.adjusted<0.05) J Heatmap of top 20 clusters of orthologous genes (COG) abundance profiles for Lactobacillus isolates and nearest phylogenetic neighbors with warmer colors indicating increasing number of genes assigned to each COG

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