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Fig. 5 | Microbiome

Fig. 5

From: Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis

Fig. 5

Contribution of epithelial lactate fermentation to host production of lactate during DSS colitis. A–C Groups of LdhaΔIEC mice and Ldhafl/fl (Ctrl) littermates were treated with 1.5% DSS in the drinking water or received normal drinking water (mock). After 6 days of DSS treatment, mice were intragastrically administered either streptomycin or water. Samples were obtained 9 days after beginning of the DSS treatment. Luminal butyrate (A) and lactate (B) concentrations were measured in the cecum content by GC/MS. C Combined histopathology scores representing the severity of tissue damage. Columns represent geometric mean and error bars represent geometric standard deviation. Each dot represents one animal. Statistical significance was determined using a two-way ANOVA with Sidak’s multiple comparisons test. **, p<0.01; ns, not statically significant

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