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Fig. 3 | Microbiome

Fig. 3

From: Enterotypical Prevotella and three novel bacterial biomarkers in preoperative stool predict the clinical outcome of colorectal cancer

Fig. 3

Performance of microbiota-derived hazard score. A Schematic illustration for the generation of microbial hazard scores (MHS). B Performance comparison of 31 MHS in bootstrapped datasets. Logarithmic P values for the log-rank survival test (top), C-index (middle), and variance of logarithmic HR (bottom) are displayed. C PFS curve by categorized M5. D OS curve by categorized M5. E Performance comparison of M5 with other indicators. The baseline model was constructed using the cancer stage; C-index is indicated as the dotted line. Other categorized variables indicate the HR of the high-group over low group. F Adjusted HRs of the indicated biomarkers. Variables were adjusted by the pathological stage of cancer. Enterotype showed the HR of Prevotella type 2 over Bacteroides type 1. G C-index of combinatorial prognostic factors. Parenthesis includes the increased C-index following the addition of M5 to the previous model. Lym. Inv.: lymphatic invasion. The numbers at risk are presented under the survival curves

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