Skip to main content
Fig. 6 | Microbiome

Fig. 6

From: Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity

Fig. 6

B. longum_MG723 and B. bifidum_MG731 attenuate intestinal cholesterol biosynthesis in the germ-free mice to protect against HFD-induced obesity. a Volcano plots of DEGs from HFD-fed SPF mice and germ-free mice treated with vehicle, B. longum_MG723 or B. bifidum_MG731 (n = 1–2 per group). Genes for FDR < 0.05 and |log2(fold change)| > 1 were indicated in red or blue. b Network representation of enriched Gene Ontology (GO) biological processes, enriched in HFD-fed mice treated with B. longum_MG723 and B. bifidum_MG731 compared to HFD-fed mice treated with vehicle. The statistical significance was calculated using two-sided hypergeometric tests, and the false discovery rate was corrected using the Bonferroni step-down method. c Genetic network enriched in vehicle and probiotics (B. longum_MG723 and B. bifidum_MG731) from HFD-fed SPF mice. d Genetic network enriched in vehicle and probiotics (B. longum_MG723 and B. bifidum_MG731) from HFD-fed germ-free mice

Back to article page