Fig. 7From: Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western dietProposed role of Epac1 in mediating pathophysiology of WD-induced obesity. WD causes a reduction in Epac1 protein in the small intestine and WAT, resulting in increased inflammation and insulin resistance through increased pro-inflammatory TNF-α and F4/80 in the WAT and circulating adipokine LCN2Back to article page