The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis

Microbiome

Table 2 An overview of differential abundant taxa by use of ANCOM*

Sarcoidosis vs controls	Fungi		Bacteria
Sarcoidosis vs controls	OW	PBAL	OW	PBAL	LPSB
Phylum	Ascomycota W1 Fungi W1	ns	Abscondibacteria W1 Fusobacteria W1	Abscondibacteria W1	ns
Class	Sordariomycotes W10	Sacchaomycetes W13	ns	ns	Chitinophagia W4 Bacteroidetes_(C-1) W1 Mollicutes W1 Synergistia W1
Order			ns	ns	Chitinophagales W8
Family			ns	ns	Chitinophagaceae W11
Genus	ns	Candida W31	Stomatobacteria W21	ns	Synergistia W1

*Analysis of Composition of Microbes (ANCOM). Only taxa found to be significantly different (p < 0.05) between sarcoidosis patients and controls are listed. ANCOM tests whether pairwise ratios of taxa are different between study groups. The W number specifies the number of significantly different ratios. The maximum W number for each test is the number of taxa within the group 1. For example, for left protected sterile brush 20 different classes of bacteria was found, and the maximum W number would be 19. For Chitinophagia, the ratio between Chitinophagia and 4 other classes were found by ANCOM to be significantly different between sarcoidosis patients and controls

ISSN: 2049-2618