Fig. 4

Changes in the levels of total and transcriptionally active bacterial species after fluoride + arginine treatments. Each dot represents a species that was significantly under- or over-represented in the 16S rRNA sequencing, metagenomic (MTG), or metatranscriptomic (MTT) dataset after a 6-month use of a fluoride + arginine dentifrice. The abundance (y-axis) and fold change (x-axis, %before/%after) are shown for each bacterium. Dots corresponding to species over-represented after treatment with a fluoride-containing dentifrice are shown in orange, and those in green represent bacteria over-represented after brushing with a Fl+Arg dentifrice. Species differentially represented in caries-active sites (CA) are shown on the left panels while those for caries-free individuals (CF) are on the right panels. The names of the species at > 1% abundance before or after the treatment are indicated