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Fig. 1 | Microbiome

Fig. 1

From: Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression

Fig. 1

Higher relative abundance of bacterial LDH in women with a Lactobacillus-dominated microbiome. The vaginal microbiome composition of 113 young women from Cape Town, South Africa, was determined using liquid chromatography-tandem mass spectrometry, and participants were classified as being bacterial vaginosis (BV) negative, positive, or intermediate (Int) using Nugent-BV criteria. Proteins were identified using MaxQuant, and a custom database was generated using de novo sequencing to filter the UniProt database. Taxonomy was assigned using UniProt, and relative abundance of each taxon was determined by aggregating the intensity-based absolute quantification (iBAQ) values of all proteins identified for each taxon. The relative abundance of the 20 most abundant bacterial species is indicated for each participant in (A). The relative abundance of L- and D-lactate dehydrogenase (LDH) protein derived from various bacterial sources was measured in vaginal secretions using metaproteomic analyses for each participant (B)

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