Fig. 1
From: Location-specific signatures of Crohn’s disease at a multi-omics scale
Cohort and high-level feature overview. A Cohort and pipeline overview. B Density plot of disease severity, as measured by either SES-CD for CD (left) or Ulcerative Colitis Endoscopy Index of Severity (UCEIS, right) for UC. C Venn diagram of all features overlap from our cohort. Common features = 6.022, unique CD = 927, unique UC = 454. D Relative proportion each feature set contributed to the multi-omic feature set. Of note, only OGUs were used in this analysis, and thus percentage would change based on sequence annotation workflow. E Schematic of machine-learning pipeline. F Test set classification accuracy scores for individual feature sets and the multi-omic (combined) feature set across several different metadata categories. Expanded metrics (e.g., precision, recall, etc.) available in Supplementary Table S2. G Multi-omic-generated Bray-Curtis distance PCoA, colored by metadata category (listed above graph). Color scaling for SES-CD and Faith’s phylogenetic diversity (Faith’s PD) is continuous from minimal value (small dot) to maximum value (large dot)