Fig. 3

Metagenomic CRISPR diversity. A, B Number of CRISPR spacers present in the different metagenomic samples normalized by A the sequencing depth and B the sequencing depth and the species richness. (*** illustrates Wilcoxon p values < 0.001). The human microbiome data is from [53]. C The number of spacers detected in the isolated genomes of predominant and subdominant cheese community species and in the shotgun metagenomic samples. Intersections of circles shows the number of shared CRISPR spacers (intersection(1) = metagenomic and dominant species, intersection(2) = metagenomic and subdominant species, intersection(3) = only metagenomic). D The cumulative plot (rarefaction curve) of the CRISPR spacers detected in the metagenomic samples