Fig. 4

Probiotic intervention with Odoribacter laneus ameliorates glucose tolerance and inflammation in mice with diet-induced obesity. Weight evolution (a) and food consumption (b) during probiotic treatment (n = 7). Fasted serum succinate levels (n = 5–6) (c). Principal component analysis and average phylum, family, genera, and species abundance of the 10 more abundant taxa in the cecum of DIO mice treated with vehicle or O. laneus (d) (n = 6–8). Glucose tolerance test (e) (n = 7). Insulin secretion during glucose tolerance test (f) (n = 5). Insulin tolerance test (g) (n = 7). mRNA expression levels of inflammatory genes in the scWAT, vWAT, liver, and intestine (h) (n = 5). Data are presented as mean + s.e.m. *p < 0.05; **p < 0.01 (unpaired t-test and two-way ANOVA)