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Fig. 2 | Microbiome

Fig. 2

From: Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate

Fig. 2

Microbiota depletion improves glucose metabolism and reduces succinate levels in C57BL/6 diet-induced obese mice. Percentage of 16S rRNA gene detection in cecum before and after antibiotic or vehicle administration (a). Cecal short-chain fatty acid analysis: acetic acid (AA), propionic acid (PA), butyric acid (BA), indolebutyric acid (IBA), isovaleric acid (IVA), valeric acid (VA), and hexanoic acid (HA) (b) (n = 6–8). Body weight evolution (c). Food consumption (d). Glucose (e) and insulin (f) tolerance tests (n = 8–10). mRNA expression levels of inflammatory genes in the scWAT, vWAT, liver, and intestine (g) (n = 6). Succinate levels in the cecum (h), feces (i), and serum (j) (n = 6–8). Data are presented as mean + s.e.m. *p < 0.05; **p < 0.01; ***p < 0.001 (unpaired t-test and two-way ANOVA)

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