Fig. 1

Response of Min pigs and Yorkshire pigs to DSS-induced colitis. a Min pigs and Yorkshire pigs were administered CON (control, sterile saline) or DSS (4% DSS in 100 mL of water) via gavage for 5 days. The first dose had a volume of 200 mL. b Plot of the disease activity index (DAI) values of Min pigs and Yorkshire pigs against the number of days (n = 8 samples/group). DAI values were calculated as (weight loss rate score + stool consistency score + bloody stool score)/3. c Histological activity index (HAI) values of Min pigs and Yorkshire pigs after DSS treatment. Comparison of d spleen coefficient, e colon coefficient and f colon length in Min pigs and Yorkshire pigs after DSS treatment (n = 8 samples/group). g Distal colon inflammation and histopathology score of Min pigs and Yorkshire pigs after DSS treatment (n = 5 samples/group). Scale bar, 200 μm. Data are presented as the mean ± SEM and were analysed by the t-test; significance is reported as *P < 0.05, **P < 0.01