Skip to main content
Fig. 1 | Microbiome

Fig. 1

From: Antibiotic exposure prevents acquisition of beneficial metabolic functions in the preterm infant gut microbiome

Fig. 1

Maturation of the microbial community during the first three weeks of age. Ontogeny of overall microbiome composition was assessed in antibiotic-naïve preterm infants (n=46) by analyzing sequencing data for microbial diversity. A Microbiome diversity. Box and whisker plot of microbiome diversity by Shannon index using the median and interquartile ranges for each cohort. There was significantly increased microbial diversity in the week 3 compared to that in week 1; p = 0.008, <0.001, =0.002 in axilla (n=83), groin (n=86), and stool (n=89) samples respectively in antibiotic-naïve infants. B Microbiome composition. Principal component analysis (PCA) of the microbiome. Genera abundance data was subjected to generalized log2 transformation followed by PCA. Samples were then colored by group membership and ellipses represent the 95% confidence interval around the centroid of microbiome composition for each group. Arrows were drawn between the centroids to indicate the magnitude and direction of microbiome change in the first two dimensions. MRPP was used to assess the significance of difference in microbiome composition between groups. Genera composition was statistically distinct from weeks 1 to 3 between all three specimen sites, by MRPP (P <0.001)

Back to article page