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Fig. 1 | Microbiome

Fig. 1

From: TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila

Fig. 1

Gut microbiota distinguishes the colitis severity in WT mice from that in TLR4−/− mice. a TLR4 expression is upregulated in tissue samples from UC patients by NCBI GEO database. (GSE11223: healthy sample, n = 73, UC patients, n = 128; GSE87466: healthy sample, n = 21, UC patients, n = 87; GSE126124: healthy sample, n = 47, UC patients, n = 36). b Body weight change. c Survival. d Body weight change. e Survival. f Disease activity index (DAI) score. g Representative pictures of colon gross appearance. h Colon length. i Representative microscopic pictures of H&E staining (40× and 200× magnification). j Histology score. k Representative colonoscopy images. (l) Colonoscopy score. (b-l) n = 10 mice per group, mean values ± SEM are presented, and p-values were calculated using unpaired T-test, *p < 0.05, **p < 0.01, ***p < 0.001. Data are pooled from three independent experiments with n = 10 mice per group

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Microbiome

ISSN: 2049-2618

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