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Fig. 5 | Microbiome

Fig. 5

From: Gut dysbiosis promotes prostate cancer progression and docetaxel resistance via activating NF-κB-IL6-STAT3 axis

Fig. 5

The IL6-STAT3 pathway promoted prostate cancer docetaxel chemoresistance. A Western blot of relative proteins in RM-1 and DU-145 cultured with different conditions. B, C Cell viability and TUNEL assay (scale bar, 100 μm) were conducted on RM-1 and DU-145 under condition as described. D Flowchart of the NC, Docetaxel, Abx+Docetaxel, and Abx+Docetaxel+Stattic groups for in vivo study. Relevant tumor images and comparison of volume and weight for tumors in four groups (n = 5). E Immunohistochemistry of tumor tissues for p-STAT3-, Bcl-2-, and survivin-positive cell in four groups (scale bar, 50 μm). Statistical significance was assessed by LSD in one-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001

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