Fig. 1
From: Gut metabolites predict Clostridioides difficile recurrence
Prospective Clostridioides difficile infection (CDI) study measuring gut microbes and metabolites to develop recurrence predictors. Fifty-three participants with first-time CDI were followed for up to 8 weeks after initial CDI antibiotic treatment. Fecal samples were collected prior to CDI antibiotic treatment, 1 week post-treatment, and then weekly or bi-weekly until recurrence or end of the study period. Microbial composition within fecal samples was analyzed with 16s rRNA gene amplicon sequencing. Metabolites in fecal samples were measured with liquid chromatography/mass spectrometry (LC/MS) broad metabolomics and targeted short chain fatty acid profiling