Fig. 1

Overview of the analysis pipeline. Beginning with identifying a list of microorganisms that coexist with K. pneumoniae, the genome-scale metabolic models were built using KBase and the extent of benefit derived by each individual microorganism in different scenarios was computed using MetQuest and the Metabolic Support Index (MSI) as a metric. SteadyCom, a constraint-based approach, was also employed here to determine the effect of a microorganism on the growth of another and to further classify the nature of their interactions into their respective types based on the observed change in growth rates