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Fig. 7 | Microbiome

Fig. 7

From: Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates the severity of DSS colitis

Fig. 7

UC VLPs exacerbate the severity of experimental colitis in the presence of gut bacteria. A–C Data shown is from experiment “B” (trial #1). D–F Data shown is from experiment “C.” A Mean body weight change during experimental colitis induction between the indicated groups. B Mean colon length at day 5 post-DSS administration between the three groups. C Mean inflammatory cytokine production in colon tissue explant at day 5 post-DSS administration. D Mean length of the colon at day 5 post-DSS administration of the following groups: UC bacteria colonized mice treated with UC VLPs with/without DSS challenge, UC bacteria colonized mice treated with heat-killed (HK) UC VLPs and UC VLP treatment alone. E, F Mean inflammatory cytokine production in colon tissue explants of the indicated groups. A Data were analyzed by two-way ANOVA with Bonferroni for multiple comparisons. B–F Data were analyzed using a two-tailed unpaired parametric t test (*p < 0.05, **p < 0.01, ***p < 0.001). Error bars, SD. Data shown from one experiment. Each dot represents an individual mouse. UCbac, UC-HMA mice

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Microbiome

ISSN: 2049-2618

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