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Fig. 6 | Microbiome

Fig. 6

From: Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates the severity of DSS colitis

Fig. 6

UC VLP administration differentially modulates bacterial community composition in UC-HMA mice. A Mean relative abundance of Eubacterium limosum (left, data shown is from experiment “B” (trial #1) and Escherichia-Shigella sp. (right, data shown is from experiment “C”) in UC-HMA mice over time was determined using 16S rRNA gene sequencing. ANCOM II was used to confirm that these species were differentially abundant between treatment groups [50]. Error bars, SE. B Data shown is from experiment ‘B’ (trial #1). PCoA on weighted UniFrac distance between HMA mice during the bacterial colonization period, VLP gavage period, and DSS/washout period. Significant differences between weighted UniFrac distances were assessed using PERMANOVA (p ≤ 0.05) (bottom). Samples from all sampling points were included in the PCoA and comparative analyses. Mouse fecal samples in each cage were pooled from 2 mice (n=3 cages, 6 mice per treatment group). Dots represent pooled mouse fecal samples at a single sampling point. UCbac, UC-HMA mice

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