Fig. 4

The bacterial microbiota plays an important role in double Dectin-deficient mouse protection. A–C Wild-type mice from Janvier Laboratory (WTj) and Dectin-1/2 deficient (D-1/2KO) mice without challenge. WTj n = 14, D-1/2KO n = 12. A Beta diversity. Principal coordinate analysis of Jaccard distance, with each sample colored according to the genotype. B Shannon index describing the alpha diversity of the bacterial microbiota (16S) in the fecal microbiota. C Taxa with the largest differences (LDA > 2) in abundance by linear discriminant analysis (LEfSe) (LDA > 2). D WTj, D-1/2KO and WTj transplanted with the intestinal microbiota of Dectin-1/2-deficient mice (WTj^D-1/2KO) mice without challenge. WTj n = 4, D-1/2KO n = 4, WTj^D-1/2KO n = 8. D Beta diversity. Principal coordinate analysis of Jaccard distance, with each sample colored according to the genotype