Fig. 2

Running training changes gut microbial richness and community structure in mice after MI. A Pan analysis for four groups based on genus level (n = 7:18:12:12). B Fecal bacterial community at the phylum level among Sham + control, MI + control, Sham + Run, and MI + Run. C PCoA analysis based on the relative abundance of genus between Sham + control and MI + control groups. D PCoA analysis based on the relative abundance of genus between MI + control and MI + Run groups. E A total of 49 samples were clustered into enterotype 1 (green), enterotype 2 (red), and enterotype 3 (blue) at the genus level. F The percentage of Sham + control, MI + control, Sham + Run, and MI + Run samples distributed in three enterotypes. G Five changed genera among Sham + control, MI + control, Sham + Run, and MI + Run. Significant differences were assessed by ANOSIM analysis in C, D; abund jaccard analysis in E; Wilcoxon rank-sum with FDR in F. *p < 0.05, **p < 0.01, ***p < 0.001