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Fig. 7 | Microbiome

Fig. 7

From: Gut microbiota-derived ursodeoxycholic acid from neonatal dairy calves improves intestinal homeostasis and colitis to attenuate extended-spectrum β-lactamase-producing enteroaggregative Escherichia coli infection

Fig. 7

Ursodiol-FMT alleviated ESBL-EAEC-induced colitis better than did the control-FMT and placebo-FMT. a Diagram of the neonatal mouse model. Ursodiol-FMT, control-FMT, and placebo-FMT are indicated. Arrows represent the time-point of infection; circles represent the harvest time. b Daily body weight changes throughout the entire study period postinfection. Data are presented as means ± SEM (n = 6 per group). Statistical significance was determined using two-way ANOVA. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 relative to the placebo-FMT group. c DAI score kinetics for the entire study. d Colon lengths for each group. H&E-stained colonic tissues (e) and histological scores (f; n = 6 per group). g Relative abundances of fecal bacterial families in 99.5% of the community. h Analysis of differences in enriched microbiota taxa shown by LEfSe (linear discriminant analysis (LDA) coupled with effect size measurements) upon FMT

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Microbiome

ISSN: 2049-2618

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