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Fig. 6 | Microbiome

Fig. 6

From: Gut microbiota-derived ursodeoxycholic acid from neonatal dairy calves improves intestinal homeostasis and colitis to attenuate extended-spectrum β-lactamase-producing enteroaggregative Escherichia coli infection

Fig. 6

Ursodiol intervention alleviated ESBL-EAEC-induced colitis in a neonatal mouse oral-infection model. a Illustration of the mouse infection model. Arrows represent the time-point of infection; circles represent the harvest time. b Daily body weight changes post-treatment. Data are presented as means ± SEM (n = 6 per group). Statistical significance was determined using two-way ANOVA. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 relative to the 1587+ursodiol-treated group. c DAI score kinetics for the entire study. d Colon lengths from each group. H&E-stained colonic tissues (e) and histological scores (f; n = 6 per group). g Western blot analysis of the NF-κB pathway activation and cell tight junctions. Relative fold changes of p-IκBα (h) and occludin (i) are presented as means ± SEM. Statistical significance was analyzed using unpaired t-tests. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001

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Microbiome

ISSN: 2049-2618

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