Table 2 Changes in the oral microbiome associated with pancreatic cancer
From: The oral microbiome, pancreatic cancer and human diversity in the age of precision medicine
Author (year) | Participants (n) | Study Type | Findings | Location |
|---|---|---|---|---|
Fan et al. (2018) [36] | 361 PC and 371 matched controls | Prospective cohort study | P.gingivalis and A. actinomycetemcomitans are associated with PC. Phylum Fusobacteria and genus Leptotrichia are associated with decreased PC risk. | United States |
Michaud et al. (2013) [37] | 405 PC and 416 matched controls | Prospective cohort study | Antibodies to P. gingivalis increased PC risk twofold, specifically to strain ATCC 53978. | European Countries |
Vogtmann et al. (2020) [38] | 273 PC and 285 matched controls | Comparative Study | Enterobacteriaceae, Lachnospiraceae G7, Bacteroidaceae, or Staphylococcaceae were associated with PC. Haemophilus decreased odds of PC. | Iran |
Farrell et al. (2012) [39] | 10 PC and 10 healthy controls Validation: 28 PC, 27 chronic pancreatitis, 28 controls | Comparative study | N. elongata and S. mitis are decreased and G. adiacens is increased in PC. G. adiacens and S. mitis are increased in PC when compared to chronic pancreatitis. | United States |
Lin et al. (2013) [40] | 12 PC, 3 pancreatitis, 12 healthy controls | Comparative study | Bacterioides genus are increased in PC. Corynebacterium and Aggregatibacter are decreased in PC. | United States |
Torres et al. (2015) [41] | 108 PC, 78 “other diseases,” 22 healthy controls | Comparative Study | Increased ratio of Leptotrichia to Porphyromonas in PC. No difference in S. mitis and G. adacians in PC. | United States |
Wei et al. (2020) [42] | 41 PC, 69 healthy controls | Comparative Study | Streptococcus and Leptotrichina increased in PC. Veillonella and Neisseria increased in controls. | China |
Olson et al. (2017) [43] | 34 PC, 39 IPMN, 58 controls | Comparative Study | Increased proportion of Firmicutes phylum in PC. | United States |