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Fig. 3 | Microbiome

Fig. 3

From: The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids

Fig. 3

BCCAO causes hippocampal injury, neuroinflammation, and SCFA metabolic disorder. A–C Quantitative analysis of hippocampal neurons via immunofluorescence staining: A Immunofluorescence staining of hippocampal neuron. Scale bar, 1 mm. B Bar plots showing the mean fluorescence intensity (n = 5 Sham, n = 6 BCCAO) and C representative images of the cornu ammonis (CA) 1, CA2, CA3, and dentate gyrus (DG) zones. Scale bar, 50 μm. D TUNEL staining of hippocampal neurons. Scale bar, 30 μm. E mRNA levels of inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-4, and IL-10) in the hippocampus (n = 6/group). F Bar plots showing hippocampal levels of acetic acid, propionic acid, butyric acid, and hexanoic acid (n = 6/group). The data represent the mean ± SEM, p < 0.05 was set as the threshold for significance. * p < 0.05, *** p < 0.001 compared to the sham group

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Microbiome

ISSN: 2049-2618

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