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Fig. 6 | Microbiome

Fig. 6

From: Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Fig. 6

Integrative analysis of baseline gut microbial signatures, immune activation-related transcripts, bacterial proteins and HIV-1 reservoir. a Spearman’s correlations between the ratio Bacteroidales/Clostridiales and DEGs (annotated transcripts). Color and size of the circles indicate the magnitude of the correlation. White asterisks indicate significant correlations (*p < 0.05; **p < 0.01; ***p < 0.001, Benjamini–Hochberg adjustment for multiple comparisons). b Network visualizing significant Spearman’s correlations between the ratio Bacteroidales/Clostridiales and transcripts involved in the enrichment analysis described in Additional file 3: Table S4. Transcripts are represented as vertices and border width is proportional to transcript expression (log2 |cpmTMM_w0 +1|) in controllers. Edge width indicates the magnitude of correlation. c Network showing Spearman's correlation between viral reservoir (CA HIV-1 RNA and HIV-1 DNA), bacterial species within Bacteroidales and Clostrdiales, host transcripts correlated with the ratio Bacteroidales/Clostrdiales and bacterial proteins (p ≤ 0.025). Features are showed as vertices and colored by ‘omic’ dataset. Edge width indicates the magnitude of correlation coefficient. Protein-associated bacterial genera are reported in parentheses. In all panels, positive and negative correlations are indicated in blue and red, respectively. Abbreviations: DEGs, differentially expressed genes between controllers and non-controllers; R, Ruminococcus; Ps, Pseudoflavonifactor and pre-Vax, baseline timepoint (1 day before first MVA vaccination)

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