Fig. 3
Virus community clusters in plasma (sample number: nP = 45). A Co-occurrence network of viral abundances in patient plasma. Nodes represent core viral species shaped according to TTV genogroups (TTV1-5), Beta- (BTV) and Gamma torque virus (GTV) or non-Anelloviruses (nonAnello), edges depict correlation (red), and exclusion (blue). Networks were calculated iteratively removing every patient (leave-one-out strategy) to correct potential patient bias. The fused graph depicts viruses present in all subnetworks (core virome), edges present in > 50% of subnetworks, edge weight as average over the respective values in the subnetworks. B 2-dimensional PHATE ordination of distances between core viral strains in the plasma virome. Depicted clusters were inferred from partitioning around medoids of correlation matrix combined with block models of graph adjacency matrices. p < 0.001, PERMANOVA. C Association of Anellovirus genogroups and pathogenic viruses with viral clusters in blood. BTV Beta torque virus, GTV Gamma torque virus, TTV1-4 Alpha torque virus genogroups, nonTTV pathogenic viruses. Pearson χ2 test, association strength color-coded, circle size depicts normalized strength, χ2 = 50, p < 0.0001