Fig. 6

Integration of skin bacterial microbiome and metabolome identifies a Bd infection-associated multi-omics signature. DIABLO sample plots demonstrating discrimination of Bd-exposed and un-exposed midwife toads based on a) skin bacterial microbiome and b) skin metabolome c) bacterial taxa contributing separation along component 1 in (a). Bar length indicates loading coefficient weight of selected bacterial ASVs. Bar colour indicates the group in which the bacterial ASV has the highest median abundance, blue = control, red = Bd exposed. d Clustered image map (Euclidean distance, complete linkage) of the multi-omics signature. Samples are represented in rows, selected features of the first component are shown in columns. Sample sizes: Control = 20, Bd exposed = 20