Table 1 PERMANOVA and MaAsLin results investigating the effect of perinatal factors on bacterial and fungal microbiota composition for each respiratory site. Multivariable model PERMANOVA results are represented with the effect size (R2) and corresponding p value. PERMANOVA results with a p value < 0.05 are highlighted with dashed lines. For MaAsLin results, integers represent the number of Differentially Abundant (DA) ASVs for a given factor. Factors of interest with PERMANOVA p values < 0.05 and at least 1 differentially abundant ASV are highlighted with dashed lines
From: Early life inter-kingdom interactions shape the immunological environment of the airways
Nasal Bacteria | Nasal Fungi | Oropharyngeal Bacteria | Oropharyngeal Fungi | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
PERMANOVA | MaAsLin | PERMANOVA | MaAsLin | PERMANOVA | MaAsLin | PERMANOVA | MaAsLin | |||||
R2 | P-value | DA ASVs | R2 | P-value | DA ASVs | R2 | P-value | DA ASVs | R2 | P-value | DA ASVs | |
Gestational age at birth | 0.050 | 0.917 | 1 | 0.060 | 0.369 | 2 | 0.065 | 0.090 | None | 0.075 | 0.779 | None |
Delivery mode | 0.006 | 0.938 | None | 0.012 | 0.658 | None | 0.009 | 0.362 | None | 0.018 | 0.684 | None |
Breastfeeding | 0.015 | 0.280 | None | 0.018 | 0.197 | 1 | 0.038 | 0.003 | 6 | 0.047 | 0.011 | 5 |
Country | 0.015 | 0.306 | None | 0.032 | 0.007 | 1 | 0.021 | 0.048 | None | 0.038 | 0.044 | None |
Gender | 0.007 | 0.902 | None | 0.012 | 0.679 | None | 0.007 | 0.512 | None | 0.026 | 0.290 | None |