Fig. 4

Bacterial clustering based on bacteria bound IgA and IgG. A Examples of contour plots of IgA- and IgG-coated bacterial populations. The double negative population (DN) is shown in blue, the double positive population (DP) is shown in orange and the IgA dominant (IgAd) is shown in green. Contour plots of a participant with L. crispatus-dominated vaginal microbiota (VH16) and a participant with non-L. crispatus-dominated vaginal microbiota (VH10). B Heat map depicting the percentage of bacterial cells per population (DN = double negative, DP = double positive and IgA dominant population). C The linear discriminant analysis (LDA) effect size analysis for the appearance of an IgA dominant population with an alpha-value set to 0.01. The linear discrimimant analysis (LDA) score for the taxon more prevalent in women with a IgA dominant population at T = 2 and/or T = 3 is shown in green, the LDA score for the taxon more prevalent in women without an IgA dominant population is shown in red