Fig. 6

Akkermansia muciniphila (AK) treatment improves healthy lifespan. a Frailty index and b discrimination index of AK-treated and untreated aged mice. c Weight of soleus, tibialis anterior (TA) and gastrocnemius (gastro) skeletal muscles. d Grip strength comparison between AK-treated and untreated aged mice. e Pictures are representative images of laminin-stained TA muscles (left panel). Mean TA fibre size (right panel). f Frequency distribution of cross-sectional TA fibre area. g qRT-PCR analysis of MyHC, Igf-1 and Pax7 mRNA expression in TA muscle of the aged mice treated with AK. Data are presented as means ± SEMs (*P < 0.05, two-tailed Student’s test)