Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement

Table 2 Associations between changes in resting-state functional connectivity and DTI after CBT with clinical measures in responders

Changes in functional connectivity after CBT are associated with clinical measures in responders
Dyad with reduced connectivity	Clinical measure	r	df	p value	q value
Right aINS—right PoPl	Unpleasantness rating of IBS symptoms	−.33	49	.02	.036
Left aINS—right aMCC	POMS positive score	.29	49	.039	.036
Brainstem—left SupTGLp	POMS positive score	.36	49	.009	.036
Brainstem—left SupTGLp	POMS negative score	−.32	49	.022	.042
Changes in DTI after CBT are associated with clinical measures in responders
DTI measure—cluster	Clinical measure	r	df	p value	q value
FA—inferior longitudinal fasciculus	PANAS positive affect	.38	41	.012	.04
ADC—brainstem	POMS—positive score	.41	42	.006	.03

Abbreviations: r partial Pearson’s correlation (controlling for age and sex), df degrees of freedom, p p value, CBT cognitive behavioral therapy, IBS irritable bowel syndrome, aMCC anterior mid-cingulate cortex, aINS anterior insula, SupTGLp lateral aspect of the superior temporal gyrus, PoPl planum polare of the superior temporal gyrus, FA fractional anisotropy, ADC apparent diffusion coefficient, POMS Profile of Mood States, PANAS Positive and Negative Affect Schedule

ISSN: 2049-2618