Fig. 4

Co-occurrence bacterial networks associated with reproductive outcomes. Co-occurrence bacterial networks in A endometrial fluid samples and B endometrial biopsy samples for each ART outcome. Each network was created by computing the co-occurring bacterial communities with significant Pearson correlation coefficients. Node properties: (i) circle size, proportional to the normalised and standardised bacterial relative abundances; (ii) colour, communities as retrieved by the Louvain algorithm. Edge properties: (i) thickness, proportional to p value of the Pearson correlation coefficient, from the most significant (thicker) to the less significant (thinner); (ii) colour, red for negative and grey for positive Pearson correlation coefficients. For association graphs, the same criteria were applied, with the thickness of the circle and colour intensity being proportional to the corresponding Pearson correlation coefficients. Pairs of bacteria without a circle have no significant Pearson correlation coefficient. BP, biochemical pregnancy; CM, clinical miscarriage; LB, live birth; NP, no pregnancy