Fig. 2
From: Microbiota in mesenteric adipose tissue from Crohn’s disease promote colitis in mice
Critical role of isolated bacterial biomarkers in CD inflammation. a The top 16 mAT bacterial biomarkers were identified by applying Random Forests regression of their relative abundance. Biomarker taxa are ranked in decreasing order of importance to the accuracy of the model. The model based on these biomarkers achieved an AUC of 0.987. b ROC analysis of these mAT bacterial biomarkers in the RF model achieved an AUC of 0.852 to classify patients with endoscopic recurrence. c Circularized plot showing the abundance of mesenteric resident bacteria isolated from different culture mediums. d Significant association of host-microbiome interactions: isolated species, immune transcripts, and differential metabolites. Network shows the significant correlations (Spearman’s correlation, p < 0.05) between two omics variables. Nodes are colored by different omics variables and sized by the number of connections. e Kaplan–Meier (KM) survival curves classify patients into high- and low-risk groups based on the major pathogens in the CD cohort