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Fig. 7 | Microbiome

Fig. 7

From: A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites

Fig. 7

The dietary fiber deficiency disturbs the gut-hippocampal axis attributable to cognition decline. Alteration of gut microbiota and the deficit of short-chain fatty acids (SCFAs) due to fiber deficiency promote adverse consequences on cognition (Step 1–7). Dietary fiber deficiency results in microbiota alteration (the decrease of microbial diversity and Bacteroidetes, and increase of Proteobacteria) (1) and the deficit of SCFAs and their associated inactivation of GPR41 and GRP43 (2 and 3), thereby attributable to mucus and epithelial barrier deficit (4), over translocation of LPS (the out membrane of Proteobacteria) into the blood circulation (5), systemic inflammatory tone to activate microglia (6) and thereafter synapse engulfment and synaptic proteins alteration in the hippocampus (Hippo) (7). Therefore, dietary fiber deficiency leads to an adverse impact on brain function via the gut-hippocampal axis

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Microbiome

ISSN: 2049-2618

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