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Fig. 2 | Microbiome

Fig. 2

From: A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites

Fig. 2

Dietary fiber deficiency for 15 weeks altered synaptic proteome in the hippocampus. AE The quantitative analysis of the global proteome of the hippocampus (n = 3). A Volcano plot of differentially expressed proteins. B Analysis of GO enrichment of biological process for differentially expressed proteins. C Analysis of KEGG pathway of the differentially expressed synaptic proteins. D The heatmap of the differentially expressed synaptic proteins. E PPI network analysis of distinctly dysregulated proteins based on STRING database and Cytoscape 3.6.0. Black lines denoted the interaction between two proteins. The red node signified up-regulation, blue node signified downregulation. FH The verification of the quantitative analysis of the global proteome of the hippocampus for downregulated proteins (CaMKIId, GAP43, and SV2C) by western blot (n = 5–6). Values are mean ± SEM. *p < 0.05 fiber deficiency (FD) group vs. control (Con) group

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